By Gerhard Krauss
Initially in response to a graduate direction taught via the writer, this actual vintage has once more been commonly up to date to include key new findings in organic signaling. With over half the content material re-written, plus 70 fresh and 50 revised figures, this is often the main updated textbook on signaling to be had anyplace.
Thanks to its transparent constitution, enormous quantities of illustrative drawings, in addition to bankruptcy introductions and newly further research questions, this article excels as a significant other for a direction on organic signaling, and both as an introductory connection with the sphere for college students and researchers. Generations of scholars and junior researchers have depended on "the Krauss" to discover their method throughout the bewildering complexity of organic signaling pathways.
Read or Download Biochemistry of Signal Transduction and Regulation (Lecture Notes Series) PDF
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Additional info for Biochemistry of Signal Transduction and Regulation (Lecture Notes Series)
Eight. five Adaptor Molecules of Intracellular sign Transduction. . . . . . . . . . . . . . . . 319 312 313 315 318 XVIII Contents bankruptcy nine sign Transmission through Ras Proteins nine. 1 normal significance and category of Ras Proteins . . . . . . . . . . . . . . . . 324 nine. 2 nine. 2. 1 nine. 2. 2 nine. 2. three constitution and Biochemical homes of Ras Protein . . . . . . . . . . . . . . . . . . constitution of the GTP- and GDP-bound sorts of Ras Protein . . . . . . . . . . GTP Hydrolysis: Mechanism and Stimulation via hole Proteins . . . . . . . . . constitution and Biochemical houses of remodeling Mutants of Ras Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 327 327 328 333 nine. three Membrane Localization of Ras Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 334 nine. four nine. four. 1 nine. four. 2 GTPase-activating Protein (GAP) in Ras sign Transduction . . . . . . . . . . 335 constitution of Ras-GAP Protein. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 335 functionality of Ras-GAP Protein . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 336 nine. five nine. five. 1 nine. five. 2 Guanine Nucleotide trade components (GEFs) in sign Transduction through Ras Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 336 significance of GEFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 337 constitution and Activation of GEFs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 338 nine. 6 nine. 6. 1 nine. 6. 2 nine. 6. three Raf Kinase as an Effector of sign Transduction by means of Ras Proteins . . . . . . . constitution of Raf Kinase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . interplay of Raf Kinase with Ras Protein . . . . . . . . . . . . . . . . . . . . . . . . . . Mechanism of Activation and legislation of Raf Kinase . . . . . . . . . . . . . . . nine. 7 Reception and Transmission of a number of indications via Ras Protein. . . . . . . . . 343 340 340 341 342 bankruptcy 10 Intracellular sign Transduction: the Protein Cascades of the MAP Kinase Pathways 10. 1 elements of the MAPK Pathway . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 352 10. 2 enter indications and Substrates of the MAPK Pathways! o . . . . . . . . . . . . . . . . 354 10. three The JNK Signaling Cascade . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 356 Contents XIX bankruptcy eleven Membrane Receptors with linked Tyrosine Kinase task eleven. 1 eleven. 1. 1 eleven. 1. 2 eleven. 1. three eleven. 1. three. 1 eleven. 1. three. 2 Cytokines and Cytokine Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . constitution and serve as of Cytokine Receptors . . . . . . . . . . . . . . . . . . . . . . Activation of Cytoplasmic Tyrosine Kinases . . . . . . . . . . . . . . . . . . . . . . . . . The Jak-Stat Pathway . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Janus Kinases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Stat Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 358 359 362 364 364 365 eleven. 2 eleven. 2. 1 eleven. 2. 2 T and B phone Antigen Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369 Receptor constitution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 369 Intracellular sign Molecules of the T and B mobile Antigen Receptors . . 371 eleven. three sign Transduction through Integrins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 371 bankruptcy 12 different Receptor sessions 12. 1 12. 1. 1 12. 1. 2 Receptors with Intrinsic Ser/Thr Kinase job: the TGFb Receptor and the Smad Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .