Now up-to-date - the authoritative reference on essentially the most interesting and hard parts of the fashionable chemical industry
This hugely readable and informative reference keeps to take a entire, in-depth view of the goods, markets, and know-how of the high quality chemical compounds and company. Dr. Peter Pollak, one of many most efficient experts within the box, offers an insider's certain viewpoint on superb chemical compounds from either a technological and a advertisement point of view, protecting all fresh advancements. He offers plentiful proof and figures together with sixty-three tables, thirty figures, and nineteen photograph inserts - making this a well-illustrated and documented text.
This reference is split into 3 parts:
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Part One: The discusses the categories of excellent chemical businesses, the diversity of goods and prone, the function of analysis and improvement, the underlying applied sciences, and the demanding situations dealing with management
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Part : The company explores the main markets for nice chemical compounds - akin to the pharmaceutical, agrochemical, and animal overall healthiness industries - and the appropriate advertising thoughts, in addition to the bits and bobs of pricing, distribution channels, highbrow estate rights, account administration, and promotion
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Part 3: Outlook examines developments akin to globalization and outsourcing, forecasts destiny development and improvement via phase, and discusses must haves for achievement within the field
This re-creation beneficial properties either up to date and new info at the offer/demand stability for high quality chemical substances and the escalating influence of rising businesses in Asia, relatively from China and India. It describes the inversion of the mergers and acquisitions state of affairs from a seller's to a buyer's marketplace, the broadening of the fantastic chemical company version, and the increasing function of biotechnology, in addition to the influence of elevated outsourcing of chemical production and the becoming intake of prescription drugs and agrochemicals via the lifestyles technological know-how undefined. additionally integrated are a number of molecular buildings, engineering diagrams, and tables to facilitate understanding.
For an intensive realizing of the expertise, the company, and the way forward for the fantastic chemical compounds undefined, this book's perception is remarkable. it truly is ideal for these within the - together with staff, providers, buyers, traders, and consulting businesses - in addition to educational and different learn firms, scholars and educators, public officers, media representatives, and somebody else who desires to comprehend the intricacies of the industry.
Fine Chemicals has been well-known as Outstanding educational name 2012 (Choice, v.50, no. 05, January 2013).
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Additional info for Fine Chemicals: The Industry and the Business
Key information of the pinnacle 10 blockbuster medicines are indexed in desk eleven. three, and their structural formulation are offered desk eleven. three best 10 Proprietary medications model API Lipitor Plavix Atorvastatin (I) Clopidogrel (II) Enbrel Etanecerpt HMW Advair/Seretide Salmeterol + (IIIa) Fluticasone (IIIb) Infliximab HMW Remicade Avastin Diovan & Co-Diovan Mabthera/Rituxan Abilifly Bevacizumab HMW Valsartan (IV) Humira overall most sensible 10a Adalimubab HMW Rituximab HMW Aripiprazol (V) corporation revenues 2009 ($ billion) Pfizer Bristol-Myers Squibb Sanofi-Aventis Amgen, Pfizer, Takeda GlaxoSmithKline 12. five 10. zero Johnson & Johnson, Merck Roche Novartis 6. nine Roche Bristol-Myers Squibb Sanofi-Aventis Abbott eight. zero 7. eight 6. zero 6. zero five. nine five. 6 five. five seventy four. 2 a 11–20: (Figures in $ billion) Herceptin (trastuzumab), Roche, $5. 1; Nexium (esomeprazol), AstraZeneca, five. zero; Zyprexa (olanzapine), Eli Lilly, four. nine; Seroquel (quetiapine), AZ, Astrella,4. nine; Crestor (rosuvastatin), AZ, four. 7; Singulair (montelukast), Merck, four. 7; Neulasta/Neupogen (PEGfilgrastin/filgastrin), Amgen, four. 6; Effexor (venlafaxin), Pfizer, four. three; Lantus (insulin glargine), Sanofi-Aventis, four. three; Lovenox (enoxaparin), Sanofi-Aventis, four. 2. Σ11–20 = $46. 7 billion; ΣΣ1–20 = $120. nine billion. resource: Knol, corporation Annual stories 2009. c11. indd 112 12/17/2010 10:28:40 AM 113 PHARMACEUTICAL undefined desk eleven. four best 5 Small-Molecule Proprietary Drugs/Structural formulation H3C O CH3 N H OH F OH HO COOH N S CH3 O O H CH3 F O CH3 CH3 H O F F (I) Atorvastatin O (IIIb) Fluticasone proprionate OCH3 H3C O H3C N S N CH3 COOH N HN Cl N N (II) Clopidogrel (IV) Valsartan OH HO H N N O O H N O N HO Cl (IIIa) Salmeterol Cl (V) Aripiprazole notice: purely the structural formulation of the LMW APIs are proven. resource: The Merck Index. in desk eleven. four. 5 of the pinnacle 10 and eight of the head 20 best-selling medicinal drugs are high-molecular-weight (HMW), aka biopharmaceuticals. even though, with a standard molecular weight exceeding four hundred, the “small” lowmolecular-weight (LMW) molecules additionally convey really advanced constructions. On ordinary, they express 3 cyclic moieties (see additionally paragraph five, below). inside of 10 out of the pinnacle 12, a minimum of one is N-heterocyclic. The largest-selling nonproprietary medicinal drugs are paracetamol, omeprazole, ethinylestradiol, amoxicillin, pyridoxine, and ascorbic acid. 2. place within the Drug existence Cycle. A drug’s place within the lifestyles cycle affects exceptionally the interface with an excellent chemical corporation. the results for the choice of goal items are mentioned intimately in part 12. 2. three. Patent prestige. medicines produced less than legitimate product and production patents are often called patented, proprietary, innovator, or moral c11. indd 113 12/17/2010 10:28:40 AM 114 client BASE medications. They account for the biggest a part of international drug revenues. The prime pharmaceutical businesses are lively basically during this type. It has misplaced a part of its glory, as fewer new items arrive and extra outdated items drop out. medicinal drugs whose patents have expired are known as off-patent, nonproprietary medications, or generics.