By Otto Snow
Love medicines is a sequel to Amphetamine Syntheses (2002) accelerated insurance of the synthesis of MDMA and different empathogens and stimulants.
Expanding the chemistry of empathogens. MDMA from scratch. Small and big scale creation is defined intimately. scorching new formulation abound. Piperonyl-acetone from either safrol and isosafrol. a number of relief equipment utilizing universal and in the neighborhood to be had metals.
MDA seemed within the Sixties and has been known as the unique love drug. It used to be the 1st in a chain of molecules that produce empathy in people. MDMA was once seemed sporadically within the Nineteen Seventies. MDEA ecstasy within the 1980s.
These molecules have been managed as they have been being abused. Substituted phenyl amino-butanes have decreased abuse power and bigger safeguard margins. but, in two decades, the improvement of more secure entactogens has now not taken place.
Love medicines offers the reader a glance on the so much cutting edge chemistry for entactogen creation. particular descriptions on safrol, apiol, asarone, dimethoxyallybenzene, and so forth. extraction from a number of botanical assets. experiences of traditional syntheses with information from the unique chemists. Love medicines is an within investigate the chemistry of the entactogens, current and destiny. Reactions were translated into English. thousands around the globe have used MDMA as a healing tool.
There is an unlimited variety of new entactogens at the horizon. one hundred fifty+ references. colour disguise. UV Laminated.
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35 w. , sixty eight% yield. (c) The response was once performed as in (a) above utilizing a hundred and fifty v. of dimethyl sulfoxide. The heating time was once 70 mins. Yield eight. nine w. , seventy three percent. (f) Dimethyl sulfoxide (500 v. ) and methylene chloride (100 v. ) have been heated at 125-130° C. below nitrogen, in an gear designed to permit the addition of strong fabrics individually and concurrently. Catechol pellets (110 w. in five. five w. parts) and sodium hydroxide pellets (83 w. in four. 15 w. parts) have been extra at five minute durations, the complete addition time being a hundred and five mins. The response mix used to be stirred good all through and the interior t e m p e r a t u r e was once maintained at 125-130° C. Twenty mins after the addition of catechol and sodium hydroxide was once whole, extra parts of methylene chloride (20 w. ) and sodium hydroxide (3 w. ) have been extra at 125-130° C. The response used to be stirred at this temperature for yet another 70 mins after which the solids addition head was once changed via a Vigreux column and a relentless take-off distillation head. Water (50 v. ) was once additional and the methylenedioxybenzene/water azeotrope used to be distilled off at 98-100° C , extra water being extra slowly to the response combination as distillation proceeded. Methylenedioxybenzene now not separated from the distillate after nearly six hundred v. of distillate were accrued. Distillation of the residue then recovered dimethyl sulfoxide (490 v. ). The m e t h y l e n e d i o x y b e n z e n e layer used to be s e p a r a t e d and t h e aqueous layer extracted with ether (3 x 50 v. portions). The mixed methylenedioxybenzene and ether extract used to be dried and distilled. The yield of methylenedioxybenzene was once 91%, B. P. 173-175° C. /760 torr. practise of Piperonal 3,4-Methylenedioxybenzaldehyde The r e a c t i o n w a s c a r r i e d out as in E x a m p l e 1(f) u s i n g protocatechuic aldehyde (13. eight w. ) and the product was once remoted from the response combination by way of steam distillation. Piperonal used to be remoted in sixty one% yield and used to be pointed out by way of comparability with an actual pattern. resource: Cornforth 1969 Preparation of Protocatechualdehyde 159 guidance of Protocatechualdehyde by way of Sumio Umemura, Nagaaki Takamitsu, Takuji Enomiya, Hiroshi Shiraishi, and Takato N a okay a m u r a Ube, J a p a n J a n u a r y sixteen, 1978 instance 1 To forty five mL. of a 2 N aqueous resolution of sodium hydroxide have been extra five. 50 g of catechol, 14. 25 g of a 20 wt % aqueous answer of glyoxylic acid and a couple of. 50 g of aluminium oxide [manufactured by means of Kishida Chem. Co. , Ltd. , alternate identify: Kassei Alumina], and the aggregate was once subjected to response with stirring at 25° C. for twenty-four hours. The aluminium oxide was once separated from the response blend via filtration and hence a response liquid used to be got. The aluminium oxide separated through filtration was once washed with 20 mL. of a 1 N aqueous resolution of sodium hydroxide and the showering was once extra to the response liquid. The response liquid was once adjusted to pH 6 via the addition of a 12 N hydrochloric acid after which the unaltered catechol used to be extracted thrice with 50 mL.