By Florencio Zaragoza Dörwald
So much syntheses within the chemical learn laboratory fail and typically require numerous makes an attempt ahead of continuing satisfactorily. Failed syntheses aren't merely discouraging and complex, but additionally price loads of time and cash. Many mess ups could, notwithstanding, be kept away from by means of figuring out the structure-reactivity dating of natural compounds.
This textbook highlights the competing approaches and boundaries of crucial reactions utilized in natural synthesis. via permitting chemists to speedy realize strength difficulties this booklet may help to enhance their potency and success-rate. A needs to for each graduate scholar but in addition for each chemist in and academia.
Contents:
1 natural Synthesis: normal Remarks
2 Stereoelectronic results and Reactivity
three the steadiness of natural Compounds
four Aliphatic Nucleophilic Substitutions: frustrating Electrophiles
five The Alkylation of Carbanions
6 The Alkylation of Heteroatoms
7 The Acylation of Heteroatoms
eight Palladium-Catalyzed C-C Bond Formation
nine Cyclizations
10 Monofunctionalization of Symmetric Difunctional Substrates
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Extra resources for Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design
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